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FICUV

Fundación Hospital Clínico Universitario de Valencia

Instituto de Investigación Sanitaria INCLIVA. Valencia

Toral M, Gómez-Guzmán M, Jimenez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo A, Perez-Vizcaino F, Gálvez J, Duarte J Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. J. Hypertens. 2015; 33: 1831-44
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Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A, Valverde MA, Marrugat J, Ois A, Giralt-Steinhauer E, Sanchis J, Escolar G, Hermenegildo C, Heras M, Roquer J Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS ONE 2015; 10: e0132415
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Laguna-Fernandez A, Novella S, Bueno-Betí C, Marrugat J, Hermenegildo C Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway. Vascul. Pharmacol. 2015; 73: 104-14
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Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke. J. Mol. Cell. Cardiol. 2015; 80: 146-55
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Sanchis J, Núñez E, Ruiz V, Bonanad C, Fernández J, Cauli O, García-Blas S, Mainar L, Valero E, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Núñez J Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes. Can J Cardiol 2015; 31: 1462-8
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Escudero P, Martinez de Marañón A, Collado A, Gonzalez-Navarro H, Hermenegildo C, Peiró C, Piqueras L, Sanz MJ Combined sub-optimal doses of rosuvastatin and bexarotene impair angiotensin II-induced arterial mononuclear cell adhesion through inhibition of Nox5 signaling pathways and increased RXR/PPARα and RXR/PPARγ interactions. Antioxid. Redox Signal. 2015; 22: 901-20
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Sanchis J, Bonanad C, Ruiz V, Fernández J, García-Blas S, Mainar L, Ventura S, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Bertomeu-González V, Núñez E, Núñez J Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome. Am. Heart J. 2014; 168: 784-91
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Bodí V, Ruiz-Nodar JM, Feliu E, Minana G, Nunez J, Husser O, Martinez-Elvira J, Ruiz A, Bonanad C, Monmeneu JV, Lopez-Lereu MP, Forteza MJ, de Dios E, Hervas A, Moratal D, Gómez C, Mainar L, Sanchis J, Mainar V, Valencia J, Diaz A, Noguera I, Chaustre F, Chorro FJ Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine. Int. J. Cardiol. 2014; 175: 138-46
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Forteza MJ, Novella S, Trapero I, Hermenegildo C, Ruiz-Sauri A, Chaustre F, Bonanad C, Oltra R, Palacios L, O'Connor JE, Chorro FJ, Bodí V Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction. Eur. J. Clin. Invest. 2014; 44: 46-53
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Pineda B, Serna E, Laguna-Fernandez A, Noguera I, Panach L, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MA Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women. Bone 2014; 65: 33-41
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Bueno-Betí C, Novella S, Lázaro-Franco M, Pérez-Cremades D, Heras M, Sanchis J, Hermenegildo C An affordable method to obtain cultured endothelial cells from peripheral blood. J. Cell. Mol. Med. 2013; 17: 1475-83
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Carreño O, Sendra L, Montalvá E, Miguel A, Orbis F, Herrero MJ, Noguera I, Aliño SF, Lopez-Andujar R A surgical model for isolating the pig liver in vivo for gene therapy. Eur Surg Res 2013; 51: 47-57
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Novella S, Dantas AP, Segarra G, Vidal-Gómez X, Mompeón A, Garabito M, Hermenegildo C, Medina P Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression. Exp. Gerontol. 2013; 48: 1329-37
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Peiró C, Vallejo S, Gembardt F, Palacios E, Novella S, Azcutia V, Rodríguez-Mañas L, Hermenegildo C, Sánchez-Ferrer CF, Walther T Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas. J. Physiol. (Lond.) 2013; 591: 2275-85
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Novella S, Dantas AP, Segarra G, Novensá L, Heras M, Hermenegildo C, Medina P Aging enhances contraction to thromboxane A2 in aorta from female senescence-accelerated mice. Age (Dordr) 2013; 35: 117-28
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Tarín JJ, García-Pérez MA, Hermenegildo C, Cano A Unpredicted ovulations and conceptions during early pregnancy: an explanatory mechanism of human superfetation. Reprod. Fertil. Dev. 2013; 25: 1012-9
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Tarín JJ, Hermenegildo C, García-Pérez MA, Cano A Endocrinology and physiology of pseudocyesis. Reprod. Biol. Endocrinol. 2013; 11: 39
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Novella S, Laguna-Fernandez A, Lázaro-Franco M, Sobrino A, Bueno-Betí C, Tarín JJ, Monsalve E, Sanchis J, Hermenegildo C Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells. Mol. Cell. Endocrinol. 2013; 365: 11-6
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Pineda B, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MA Effects of administration of hormone therapy or raloxifene on the immune system and on biochemical markers of bone remodeling. Menopause 2012; 19: 319-27
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Pagán RM, Martínez AC, Hernández M, Martínez MP, García-Sacristán A, Correa C, Novella S, Hermenegildo C, Prieto D, Benedito S Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery. Biochem. Pharmacol. 2012; 83: 882-92
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Fernández-Murga L, Hermenegildo C, Tarín JJ, García-Pérez MA, Cano A Endometrial response to concurrent treatment with vaginal progesterone and transdermal estradiol. Climacteric 2012; 15: 455-9
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Novella S, Dantas AP, Segarra G, Medina P, Hermenegildo C Vascular Aging in Women: is Estrogen the Fountain of Youth? Front Physiol 2012; 3: 165
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Novella S, Heras M, Hermenegildo C, Dantas AP Effects of estrogen on vascular inflammation: a matter of timing. Arterioscler. Thromb. Vasc. Biol. 2012; 32: 2035-42
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Oviedo PJ, Sobrino A, Novella S, Rius C, Laguna-Fernandez A, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C Progestogens reduce thromboxane production by cultured human endothelial cells. Climacteric 2011; 14: 41-8
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Novensá L, Novella S, Medina P, Segarra G, Castillo N, Heras M, Hermenegildo C, Dantas AP Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice. PLoS ONE 2011; 6: e25335
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Oviedo PJ, Sobrino A, Laguna-Fernandez A, Novella S, Tarín JJ, García-Pérez MA, Sanchis J, Cano A, Hermenegildo C Estradiol induces endothelial cell migration and proliferation through estrogen receptor-enhanced RhoA/ROCK pathway. Mol. Cell. Endocrinol. 2011; 335: 96-103
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Pineda B, Tarín JJ, Hermenegildo C, Laporta P, Cano A, García-Pérez MA Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women. Osteoporos Int 2011; 22: 1451-8
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Pineda B, Hermenegildo C, Laporta P, Tarín JJ, Cano A, García-Pérez MA Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women. J. Bone Miner. Metab. 2010; 28: 696-705
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Rius C, Abu-Taha M, Hermenegildo C, Piqueras L, Cerda-Nicolas JM, Issekutz AC, Estañ L, Cortijo J, Morcillo EJ, Orallo F, Sanz MJ Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation. J. Immunol. 2010; 185: 3718-27
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Pineda B, Hermenegildo C, Tarín JJ, Laporta P, Cano A, García-Pérez MA Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion. Fertil. Steril. 2010; 93: 1809-15
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Sobrino A, Oviedo PJ, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J. Mol. Endocrinol. 2010; 44: 237-46
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Novella S, Dantas AP, Segarra G, Novensá L, Bueno C, Heras M, Hermenegildo C, Medina P Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice. Exp. Gerontol. 2010; 45: 868-74
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Pineda B, García-Pérez MA, Vázquez F, Juliá MD, Tarín JJ, Hermenegildo C, Cano A No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 144: 93-4
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Sobrino A, Mata M, Laguna-Fernandez A, Novella S, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. PLoS ONE 2009; 4: e8242
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García-Palomares S, Pertusa JF, Miñarro J, García-Pérez MA, Hermenegildo C, Rausell F, Cano A, Tarín JJ Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring. Biol. Reprod. 2009; 80: 337-42
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Abu-Taha M, Rius C, Hermenegildo C, Noguera I, Cerda-Nicolas JM, Issekutz AC, Jose PJ, Cortijo J, Morcillo EJ, Sanz MJ Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J. Immunol. 2009; 183: 1393-402
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García-Pérez MA, Pineda B, Hermenegildo C, Tarín JJ, Cano A Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line. Fertil. Steril. 2009; 91: 1347-50
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García-Palomares S, Navarro S, Pertusa JF, Hermenegildo C, García-Pérez MA, Rausell F, Cano A, Tarín JJ Delayed fatherhood in mice decreases reproductive fitness and longevity of offspring. Biol. Reprod. 2009; 80: 343-9
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Cano A, Dapía S, Noguera I, Pineda B, Hermenegildo C, del Val R, Caeiro JR, García-Pérez MA Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice. Osteoporos Int 2008; 19: 793-800
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Marrugat J, López-López JR, Heras M, Tamargo J, Valverde M, Valverde MA [The HERACLES Cardiovascular Network]. Rev Esp Cardiol 2008; 61: 66-75
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Hermenegildo C, Oviedo PJ, Laguna A, García-Pérez MA, Tarín JJ, Cano A Transdermal estradiol reduces F2alpha-isoprostane levels in postmenopausal women. Menopause 2008; 15: 714-7
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Pineda B, Laporta P, Hermenegildo C, Cano A, García-Pérez MA A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women. Osteoporos Int 2008; 19: 1147-52
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Oviedo PJ, Hermenegildo C, Novella S, Tarín JJ, Cano A Are the serum levels of sCD40L modified by raloxifene in postmenopausal women? Eur. J. Obstet. Gynecol. Reprod. Biol. 2008; 140: 296-7
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Oviedo PJ, Hermenegildo C, Sobrino A, Tarín JJ, Cano A Therapeutic dosages of oral or transdermal estradiol did not modify sCD40L levels in postmenopausal women. Gynecol. Endocrinol. 2008; 24: 354-7
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Aldasoro M, Mauricio MD, Serna E, Cortina B, Medina P, Segarra G, Novella S, Vila JM Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery. Am. J. Hypertens. 2007; 20: 514-9
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Monsalve E, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells. Cardiovasc. Res. 2007; 73: 66-72
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Novella S, Martínez AC, Pagán RM, Hernández M, García-Sacristán A, González-Pinto A, González-Santos JM, Benedito S Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting. Eur J Cardiothorac Surg 2007; 32: 69-76
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Mauricio MD, Serna E, Cortina B, Novella S, Segarra G, Aldasoro M, Martínez-León JB, Vila JM Role of Ca2+-activated K+ channels on adrenergic responses of human saphenous vein. Am. J. Hypertens. 2007; 20: 78-82
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Cano A, Hermenegildo C, Oviedo P, Tarín JJ Selective estrogen receptor modulators and risk for coronary heart disease. Climacteric 2007; 10: 97-111
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Rausell F, Pertusa JF, Gómez-Piquer V, Hermenegildo C, García-Pérez MA, Cano A, Tarín JJ Beneficial effects of dithiothreitol on relative levels of glutathione S-transferase activity and thiols in oocytes, and cell number, DNA fragmentation and allocation at the blastocyst stage in the mouse. Mol. Reprod. Dev. 2007; 74: 860-9
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Oviedo PJ, Hermenegildo C, Tarín JJ, Cano A Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1. Fertil. Steril. 2007; 88: 326-32
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Cano A, Hermenegildo C, Oviedo P, Tarín JJ The risk for cardiovascular disease in women: from estrogens to selective estrogen receptor modulators. Front. Biosci. 2007; 12: 49-68
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Sanz-González SM, Cano A, Valverde MA, Hermenegildo C, Andrés V Drug targeting of estrogen receptor signaling in the cardiovascular system: preclinical and clinical studies. Curr Med Chem Cardiovasc Hematol Agents 2004; 2: 107-22
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Coordinator

Carlos Hermenegildo

Members

An initiative of