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Pineda B, Tarín JJ, Hermenegildo C, Laporta P, Cano A, García-Pérez MA

Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.

Osteoporos Int. 2011 May;22(5):1451-8, PMID: 20577873

We have analysed the association of single-nucleotide polymorphisms (SNPs) in CD40 and CD40L genes with bone mineral density (BMD) in our women. Results showed that women with TT genotype for rs1883832 (CD40) and for rs1126535 (CD40L) SNPs displayed reduced BMD and increased risk for osteopenia/osteoporosis. Our data notwithstanding, the results need to be replicated.

ENDOCRINOLOGY & METABOLISM

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