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A multidisciplinary team of investigators with expertise in Vascular and Endocrine Physiology, Molecular Biology, Biochemistry, Cell Biology, and Reproductive Biology.

The primary research line in this group is the study of the vascular effects of estrogens and other steroidal substances. To this end, a translational approach is used that ranges from endothelial cells in culture to experiments in animal models and studies of post-menopausal women undergoing hormone replacement therapy. Recently, a line of research was initiated to address the endothelial dysfunction associated with aging.

The group’s research includes studies of gene and protein expression, production of vasoactive substances, and functional studies that use the techniques of molecular biology (PCR, RT-PCR, microarrays), biochemistry (western blot, immunofluorescence, ELISA, HPLC), cell biology (primary cultures of human endothelial cells, flow cytometry), and vascular physiology (vascular reactivity). More information

The group participates in COLMAH-HERACLES and maintains collaborations with various HERACLES programme groups, as well as national and international external collaborations.

Latest publications

• Toral M, Gómez-Guzmán M, Jimenez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo A, Perez-Vizcaino F, Gálvez J, Duarte J Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. J. Hypertens. 2015; 33: 1831-44

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• Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A, Valverde MA, Marrugat J, Ois A, Giralt-Steinhauer E, Sanchis J, Escolar G, Hermenegildo C, Heras M, Roquer J Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS ONE 2015; 10: e0132415

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• Laguna-Fernandez A, Novella S, Bueno-Betí C, Marrugat J, Hermenegildo C Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway. Vascul. Pharmacol. 2015; 73: 104-14

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• Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke. J. Mol. Cell. Cardiol. 2015; 80: 146-55

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• Sanchis J, Núñez E, Ruiz V, Bonanad C, Fernández J, Cauli O, García-Blas S, Mainar L, Valero E, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Núñez J Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes. Can J Cardiol 2015; 31: 1462-8

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• Escudero P, Martinez de Marañón A, Collado A, Gonzalez-Navarro H, Hermenegildo C, Peiró C, Piqueras L, Sanz MJ Combined sub-optimal doses of rosuvastatin and bexarotene impair angiotensin II-induced arterial mononuclear cell adhesion through inhibition of Nox5 signaling pathways and increased RXR/PPARα and RXR/PPARγ interactions. Antioxid. Redox Signal. 2015; 22: 901-20

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• Sanchis J, Bonanad C, Ruiz V, Fernández J, García-Blas S, Mainar L, Ventura S, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Bertomeu-González V, Núñez E, Núñez J Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome. Am. Heart J. 2014; 168: 784-91

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• Bodí V, Ruiz-Nodar JM, Feliu E, Minana G, Nunez J, Husser O, Martinez-Elvira J, Ruiz A, Bonanad C, Monmeneu JV, Lopez-Lereu MP, Forteza MJ, de Dios E, Hervas A, Moratal D, Gómez C, Mainar L, Sanchis J, Mainar V, Valencia J, Diaz A, Noguera I, Chaustre F, Chorro FJ Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine. Int. J. Cardiol. 2014; 175: 138-46

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• Forteza MJ, Novella S, Trapero I, Hermenegildo C, Ruiz-Sauri A, Chaustre F, Bonanad C, Oltra R, Palacios L, O'Connor JE, Chorro FJ, Bodí V Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction. Eur. J. Clin. Invest. 2014; 44: 46-53

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• Pineda B, Serna E, Laguna-Fernandez A, Noguera I, Panach L, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MA Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women. Bone 2014; 65: 33-41

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