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Novensá L, Novella S, Medina P, Segarra G, Castillo N, Heras M, Hermenegildo C, Dantas AP
Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.
PLoS ONE. 2011;6(9):e25335, PMID: 21966501
Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM).
BIOLOGY
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