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The group emerged as a proposal to improve clinical and epidemiological knowledge about the people of the Canary Islands. For at least the past 50 years, this population has suffered the highest rates of Spain in mortality from diabetes and ischemic heart disease. The group consists of 6 family physicians, 5 of whom are PhDs in medicine, plus a PhD in pharmacy (immunologist) and a PhD in biology (geneticist).

The group recruited a cohort of almost 7,000 people in the general population of the 7 Canary Islands between 2000 and 2005. This cohort is named as "CDC de Canarias", with CDC meaning Cardiovascular, Diabetes, and Cancer. Currently we are working on the follow-up of this cohort and exploiting the serum and gene libraries stored during recruitment. Our results have translational potential to clinical practice, mainly in primary care, as we provide information useful for the prevention of cardiovascular risk factors in a population that may be leading the ischemic heart disease mortality in Spain since we have national statistics.

We have developed the first risk estimation charts calibrated for the Canarian population, validated a social class indicator closely linked to cardiovascular disease, developed a clinical indicator for diabetes screening, we have also measured the incidence of diabetes in the archipelago for the first time, and we have explored prospectively some possible determinants of it, including insulin resistance and Canarian ancestry. The Canary Islands is also the community with the highest prevalence of arterial hypertension in Spain, we can provide much epidemiological, genetic and serum useful information to identify some causes of it.

Latest publications

• Marcelino Rodríguez I, Oliva García J, Alemán Sánchez JJ, Almeida González D, Domínguez Coello S, Brito Díaz B, Gannar F, Rodríguez Pérez MDC, Elosua R, Cabrera de León A Lipid and inflammatory biomarker profiles in early insulin resistance. Acta Diabetol 2016; 53: 905-913

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• Pimienta González R, Couto Comba P, Rodríguez Esteban M, Alemán Sánchez JJ, Hernández Afonso J, Rodríguez Pérez MD, Marcelino Rodríguez I, Brito Díaz B, Elosua R, Cabrera de León A Incidence, Mortality and Positive Predictive Value of Type 1 Cardiorenal Syndrome in Acute Coronary Syndrome. PLoS ONE 2016; 11: e0167166

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• Cabrera de León A, Oliva García JG, Marcelino Rodríguez I, Almeida González D, Alemán Sánchez JJ, Brito Díaz B, Domínguez Coello S, Bertomeu Martínez V, Aguirre Jaime A, Rodríguez Pérez Mdel C C-peptide as a risk factor of coronary artery disease in the general population. Diab Vasc Dis Res 2015; 12: 199-207

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• Gannar F, Cabrera de León A, Brito Díaz B, Del Cristo Rodríguez Pérez M, Marcelino Rodríguez I, Ben Dahmen F, Sakly M, Attia N Social class and metabolic syndrome in populations from Tunisia and Spain. Diabetol Metab Syndr 2015; 7: 88

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• Almeida González D, Roces Varela A, Marcelino Rodríguez I, González Vera A, Delgado Sánchez M, Aznar Esquivel A, Casañas Rodríguez C, Cabrera de León A Anti-dsDNA antibodies in systemic lupus erythematosus: A combination of two quantitative methods and the ANA pattern is the most efficient strategy of detection. J. Immunol. Methods 2015; 427: 30-5

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• Brito Díaz B, Alemán Sánchez JJ, Cabrera de León A [Resting heart rate and cardiovascular disease]. Med Clin (Barc) 2014; 143: 34-8

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• Cabrera de León A, Almeida González D, González Hernández A, Juan Alemán Sánchez J, Brito Díaz B, Domínguez Coello S, Marcelino Rodríguez I, Gregorio Oliva García J, Aguirre Jaime A, Rodríguez Pérez Mdel C, Rodríguez Pérez MD The association of resistin with coronary disease in the general population. J. Atheroscler. Thromb. 2014; 21: 273-81

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• Fernández-Bergés D, Consuegra-Sanchez L, Peñafiel J, Cabrera de León A, Vila J, Félix-Redondo FJ, Segura-Fragoso A, Lapetra J, Guembe MJ, Vega T, Fitó M, Elosua R, Díaz O, Marrugat J Metabolic and inflammatory profiles of biomarkers in obesity, metabolic syndrome, and diabetes in a Mediterranean population. DARIOS Inflammatory study. Rev Esp Cardiol (Engl Ed) 2014; 67: 624-31

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• Baena-Diez JM, Grau M, Forès R, Fernández-Bergés D, Elosua R, Sorribes M, Félix-Redondo FJ, Segura A, Rigo F, Cabrera de León A, Sanz H, Marrugat J, Sala J Prevalence of atrial fibrillation and its associated factors in Spain: An analysis of 6 population-based studies. DARIOS Study. Rev Clin Esp 2014; 214: 505-12

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• González DA, Rodríguez CC, Armas LM, Varela AR, Rodríguez IM, Duarte MT, de León AC Anti-ENA profiles related with anti-SS-A/Ro. The detection of Ro52 and Ro60 according to the presence of SS-B/La, and ANA pattern and titer. Immunol. Lett. 2014; 161: 6-12

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