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This is a multidisciplinary group of researchers with experience in epidemiology, cardiology, internal medicine, genetics and bioinformatics applied to the study cardiovascular diseases. The group's primary research lines include genetic architecture, lifestyle factors, and clinical epidemiology:

• Genetic architecture of cardiovascular diseases and their classic risk factors, identifying the genetic variants associated with various cardiovascular phenotypes and analyzing the importance of gene:gene and gene:environment interactions in modulating cardiovascular risk. We are also using these genetic study results to determine whether there are causal relationships between various biomarkers and cardiovascular diseases. We have a large collection of biological samples (n>13,000 individuals representative of the population) and maintain active international collaborations.
• Lifestyles and their relationship to cardiovascular health. A very active line of research is related to physical activity, analyzing the relationship between various types of exercise and their beneficial or harmful health effects.
• Clinical epidemiology, analyzing trends in the management and prognosis of patients with acute myocardial infarction. Participation in national and international registries of patients with coronary syndrome allows the group to analyze patient characteristics and the effectiveness of various treatments at the population level.

The group's primary objective is to translate the knowledge acquired and improve the cardiovascular health of patients and of the general population. This translational concept is supported by collaborations and agreements with public agencies and private enterprise. The group has participated in the development of public health plans and of patents that are currently in the commercial development phase.

Latest publications

• Vivanco-Hidalgo RM, Gomez A, Moreira A, Díez L, Elosua R, Roquer J Prevalence of cardiovascular risk factors in people with epilepsy. Brain Behav 2017; 7: e00618

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• Iribarren C, Lu M, Jorgenson E, Martínez M, Lluís-Ganella C, Subirana I, Salas E, Elosua R Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 Thousand Individuals of European Ancestry. Circ Cardiovasc Genet 2016; 9: 531-540

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• Velescu A, Clarà A, Peñafiel J, Grau M, Dégano IR, Martí R, Ramos R, Marrugat J, Elosua R Peripheral Arterial Disease Incidence and Associated Risk Factors in a Mediterranean Population-based Cohort. The REGICOR Study. Eur J Vasc Endovasc Surg 2016; 51: 696-705

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• Sala-Vila A, Guasch-Ferré M, Hu FB, Sánchez-Tainta A, Bulló M, Serra-Mir M, López-Sabater C, Sorlí JV, Arós F, Fiol M, Muñoz MA, Serra-Majem L, Martínez JA, Corella D, Fitó M, Salas-Salvadó J, Martínez-González MA, Estruch R, Ros E Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study. J Am Heart Assoc 2016; 5:

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• Marrugat J, Elosua R, Grau M, Sayols-Baixeras S, Dégano IR Prevalence and Prognosis of High-risk Myocardial Infarction Patient Candidates to Extended Antiplatelet Therapy. Rev Esp Cardiol (Engl Ed) 2016; 69: 480-7

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• Enjuanes C, Bruguera J, Grau M, Cladellas M, Gonzalez G, Meroño O, Moliner-Borja P, Verdú JM, Farré N, Comín-Colet J Iron Status in Chronic Heart Failure: Impact on Symptoms, Functional Class and Submaximal Exercise Capacity. Rev Esp Cardiol (Engl Ed) 2016; 69: 247-55

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• Schröder H, Serra-Majem L, Subirana I, Izquierdo-Pulido M, Fitó M, Elosua R Association of increased monetary cost of dietary intake, diet quality and weight management in Spanish adults. Br. J. Nutr. 2016; 115: 817-22

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• Garcia-Gil M, Parramon D, Comas-Cufí M, Martí R, Ponjoan A, Alves-Cabratosa L, Blanch J, Petersen I, Elosua R, Grau M, Salvador B, Ramos R Role of renal function in cardiovascular risk assessment: A retrospective cohort study in a population with low incidence of coronary heart disease. Prev Med 2016; 89: 200-6

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• Soriano-Tarraga C, Jiménez-Conde J, Giralt-Steinhauer E, Mola-Caminal M, Vivanco-Hidalgo RM, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Sayols-Baixeras S, Elosua R, Roquer J Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia. Hum. Mol. Genet. 2016; 25: 609-19

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• Marrugat J, Elosua R, Icaza G, Morales-Salinas A, Dégano IR [Practicality of cardiovascular risk functions]. Medwave 2016; 16: e6792

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