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This multidisciplinary research group possesses last-generation technology and skills for proteomic and genetic analysis, as well as strong experience in translational research with samples obtained from patients with cardiovascular diseases. Our research lines are highly diverse but we would highlight a few of the studies undertaken in patients with different cardiovascular risk factors, using proteomics to attempt to identify new biomarkers of disease progression and of response to pharmacological treatment. We have extensive experience in the study of platelets and their involvement in the response to drug therapies. Using proteomic analysis, in this research line we have defined modifications in the content of proteins that differentiate between platelet responders and non-responders to antiplatelet treatment. We have recently expanded this line of research to include megacariocytes in culture. In addition, we have opened a new line of study in Talavera because a member of our group is heading the Epidemiology Services of the Talavera Hospital. This study is analyzing the plasma proteome of a patient population in that area to look for any relationships between proteome modifications and cardiovascular risk and dietary habits.

We also have several research lines studying the map of protein expression in appendages of patients with hypertension, with or without atrial fibrillation and the protein map of the vascular wall in patients will diabetes.

The group also has a major line of analysis of genetic alterations associated with sudden cardiac death. This includes agreements with sports institutions and participation in an autonomous network for the study of channelopathies that also includes the group led by Dr. Juan Tamargo at the Universidad Complutense in Madrid.

Latest publications

• Perez-Segura P, Zamorano-León JJ, Acosta D, Santos-Sancho JM, Modrego J, Caldés T, de la Hoya M, Díaz-Rubio E, Díaz-Millán I, de las Heras N, Rico Zalba LA, Lahera V, Melander O, López Farré A BRCA2 gene mutations and coagulation-associated biomarkers. Thromb. Haemost. 2016; 115: 415-23

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• Baena-Diez JM, Peñafiel J, Subirana I, Ramos R, Elosua R, Marín-Ibañez A, Guembe MJ, Rigo F, Tormo-Díaz MJ, Moreno-Iribas C, Cabré JJ, Segura A, García-Lareo M, Gómez de la Cámara A, Lapetra J, Quesada M, Marrugat J, Medrano MJ, Berjón J, Frontera G, Gavrila D, Barricarte A, Basora J, García JM, Pavone NC, Lora-Pablos D, Mayoral E, Franch J, Mata M, Castell C, Francés A, Grau M Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care 2016; 39: 1987-1995

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• Echavarria-Pinto M, Petraco R, van de Hoef TP, Gonzalo N, Nijjer S, Tarkin JM, Ibanez B, Sen S, Jiménez-Quevedo P, Nunez-Gil IJ, Nombela-Franco L, Alfonso F, Fernández-Ortiz A, Macaya C, Piek JJ, Davies J, Escaned J Fractional flow reserve and minimum Pd/Pa ratio during intravenous adenosine infusion: very similar but not always the same. EuroIntervention 2016; 11: 1013-9

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• Gabriel R, Brotons C, Tormo MJ, Segura A, Rigo F, Elosua R, Carbayo JA, Gavrila D, Moral I, Tuomilehto J, Muñiz J The ERICE-score: the new native cardiovascular score for the low-risk and aged Mediterranean population of Spain. Rev Esp Cardiol (Engl Ed) 2015; 68: 205-15

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• Sionis A, Ruiz-Nodar JM, Fernández-Ortiz A, Marín F, Abu-Assi E, Díaz-Castro O, Núñez-Gil IJ, Lidón RM Update on ischemic heart disease and intensive cardiac care. Rev Esp Cardiol (Engl Ed) 2015; 68: 234-41

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• van de Hoef TP, Meuwissen M, Escaned J, Sen S, Petraco R, van Lavieren MA, Echavarria-Pinto M, Nolte F, Nijjer S, Chamuleau SA, Voskuil M, van Eck-Smit BL, Verberne HJ, Henriques JP, Koch KT, de Winter RJ, Spaan JA, Siebes M, Tijssen JG, Davies JE, Piek JJ Head-to-head comparison of basal stenosis resistance index, instantaneous wave-free ratio, and fractional flow reserve: diagnostic accuracy for stenosis-specific myocardial ischaemia. EuroIntervention 2015; 11: 914-25

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• Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibáñez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovas JM, Sanz G, Jiménez-Borreguero LJ, Fuster V Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation 2015; 131: 2104-13

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• Alfonso F, Perez-Vizcayno MJ, Cárdenas A, García Del Blanco B, García-Touchard A, López-Minguez JR, Rivero F, Masotti M, Zueco J, Cequier A, Morís C, Fernández-Ortiz A, Escaned J, Jiménez-Quevedo P, Gonzalo N, Fernández C, Macaya C Rationale and design of the RIBS IV randomised clinical trial (drug-eluting balloons versus everolimus-eluting stents for patients with drug-eluting stent restenosis). EuroIntervention 2015; 11: 336-42

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• Sayols-Baixeras S, Lluís-Ganella C, Subirana I, Salas LA, Vilahur N, Corella D, Muñoz D, Segura A, Jiménez-Conde J, Moran S, Soriano-Tarraga C, Roquer J, López-Farré A, Marrugat J, Fitó M, Elosua R Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study. Epigenetics 2015; 10: 1156-65

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• Melander O, Modrego J, Zamorano-León JJ, Santos-Sancho JM, Lahera V, López-Farré AJ New circulating biomarkers for predicting cardiovascular death in healthy population. J. Cell. Mol. Med. 2015; 19: 2489-99

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