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Menendez C, Dueñas M, Galindo P, González-Manzano S, Jimenez R, Moreno L, Zarzuelo MJ, Rodríguez-Gómez I, Duarte J, Santos-Buelga C, Perez-Vizcaino F
Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?
Mol Nutr Food Res. 2011 Dec;55(12):1780-90, PMID: 22144045
The dietary flavonoid quercetin exerts protective cardiovascular effects. Because quercetin is rapidly metabolized into less active or inactive glucuronidated metabolites and the plasma concentrations of free quercetin are very low, a huge amount of scientific data generated along decades with the unconjugated compounds in vitro has been questioned. We aimed to determine whether glucuronidated quercetin can deconjugate in situ and whether deconjugation leads to a biological effect.
FOOD SCIENCE & TECHNOLOGY
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