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Gómez-Gil E, Navinés R, Martínez De Osaba MJ, Diaz-Ricart M, Escolar G, Salamero M, Martín-Santos R, Galán A, Gasto C

Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment.

Psychoneuroendocrinology. 2010 May;35(4):481-9, PMID: 19762159

The serotonin-1A (5-HT1A) receptor subtypes are considered as targets of a variety of antidepressant drugs. Previous studies have suggested different adaptive changes in pre- and post-synaptic 5-HT receptors in the brain after treatment with non-selective tricyclic antidepressants (TCA) and selective 5-HT re-uptake inhibitors (SSRIs). The present study aimed to investigate the adaptive effect of the TCA imipramine on the post-synaptic 5-HT1A receptor function in the hypothalamus.

ENDOCRINOLOGY & METABOLISM