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Tomás M, Vázquez E, Fernández-Fernández JM, Subirana I, Plata C, Heras M, Vila J, Marrugat J, Valverde MA, Sentí M

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction.

J. Hypertens.. 2008 Nov;26(11):2147-53, PMID: 18854754

The large conductance Ca2+ -dependent potassium channel plays a critical role in the control of vascular tone, coupling local increases in intracellular Ca2+ to membrane hyperpolarization and vascular relaxation. It also impacts blood pressure by modulating the renin-angiotensin-aldosterone system. Previous studies have shown that a polymorphism in the beta1 regulatory subunit of the Ca2+ -dependent potassium channel modulates the risk of diastolic hypertension in humans.

PERIPHERAL VASCULAR DISEASE

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