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Carbó C, Arderiu G, Escolar G, Fusté B, Cases A, Carrascal M, Abián J, Diaz-Ricart M

Differential expression of proteins from cultured endothelial cells exposed to uremic versus normal serum.

Am. J. Kidney Dis.. 2008 Apr;51(4):603-12, PMID: 18371536

Deficient hemostasis and accelerated atherosclerosis coexist in patients with chronic kidney disease. Endothelial dysfunction may be involved in the high incidence of atherothrombotic events in these patients. We established an in vitro model of endothelial dysfunction by exposing endothelial cells to uremic media and applied a proteomic approach to characterize endothelial cell dysfunction in uremia.

UROLOGY & NEPHROLOGY