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Sanz-González SM, Barquín L, García-Cao I, Roqué M, González JM, Fuster JJ, Castells MT, Flores JM, Serrano M, Andrés V

Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis.

Cardiovasc. Res.. 2007 Sep;75(4):803-12, PMID: 17570351

The tumor suppressor p53 regulates cell proliferation and apoptosis, two key processes in the pathogenesis of occlusive vascular disease. Here, we examined the consequences of heightening p53 function on neointimal lesion formation in the setting of atherosclerosis and mechanical injury.

CARDIAC & CARDIOVASCULAR SYSTEMS