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Vera R, Jimenez R, Lodi F, Sánchez M, Galisteo M, Zarzuelo A, Perez-Vizcaino F, Duarte J

Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats.

Menopause. 2007;14(5):933-40, PMID: 17667142

The soy-derived phytoestrogen genistein improves endothelial function in postmenopausal women and ovariectomized (OVX) normotensive rats. We hypothesized that genistein would improve vascular reactivity involving changes in endothelial nitric oxide synthase (NOS) expression and its regulatory proteins (caveolin and calmodulin), angiotensin II receptor, and/or oxidative status in OVX spontaneously hypertensive rats (SHRs).


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