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Batlle M, Pérez-Villa F, García-Pras E, Lázaro A, Orús J, Roqué M, Roig E

Down-regulation of matrix metalloproteinase-9 (MMP-9) expression in the myocardium of congestive heart failure patients.

Transplant. Proc.. 2007 Sep;39(7):2344-6, PMID: 17889183

Matrix metalloproteinases (MMPs) are proteolytic enzymes responsible for extracellular matrix protein degradation. They have an important role in tissue remodeling processes. Their activity is regulated at the transcriptional, translational, and posttranslational level and by tissue inhibitors (TIMPs). Our aim was to analyze whether expression changes in MMPs that degrade collagens and their inhibitors in the myocardium have an impact on ventricular remodeling and the fibrogenesis in congestive heart failure.

IMMUNOLOGY