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Sanmartín M, Fernández-Ortiz A, Fantidis P, Aragoncillo P, Fernández-Durango R, Rollín R, Alfonso F, Hernández R, Escaned J, Macaya C

Effects of bosentan on neointimal response following coronary angioplasty.

Eur. J. Clin. Invest.. 2003 Sep;33(9):762-8, PMID: 12925035

Endothelins are important vasoconstrictors and cellular-growth promoters. ETA-specific antagonists have been shown to reduce neointimal response to injury in some experimental angioplasty models. However, there is little information on the effects of dual ETA/ETB receptor blockers, such as bosentan, on neointimal proliferation following experimental coronary angioplasty.

MEDICINE, GENERAL & INTERNAL