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Pérez-Castellano N, Villacastín J, Aragoncillo P, Fantidis P, Sabaté M, García-Torrent MJ, Prieto C, Corral JM, Moreno J, Fernández-Ortiz A, Vano E, Macaya C

Pathological effects of pulmonary vein beta-radiation in a swine model.

J. Cardiovasc. Electrophysiol.. 2006 Jun;17(6):662-9, PMID: 16836719

Atrial fibrillation (AF) may be triggered by ectopic beats originating in sleeves of atrial myocardium entering the pulmonary veins (PVs). PV isolation by means of circumferential ostial or atrial radiofrequency ablation is an effective but also a difficult and long procedure, requiring extensive applications that can have serious potential complications. Our objective was to examine pathological effects of PV beta-radiation, particularly the ability to destroy PV myocardial sleeves without inducing PV stenosis and other unwanted effects, in order to establish its potential feasibility for the treatment of AF.

CARDIAC & CARDIOVASCULAR SYSTEMS