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Angiolillo DJ, Sabaté M, Fernández-Ortiz A, Macaya C

Acute stent thrombosis after early withdrawal of platelet glycoprotein IIb/IIIa antagonists: potential rebound prothrombotic effect?

Catheter Cardiovasc Interv. 2003 Apr;58(4):481-4, PMID: 12652499

We report on two cases of acute coronary stent thrombosis after early withdrawal of different competitive inhibitors of the platelet glycoprotein IIb/IIIa receptor, eptifibatide and tirofiban. Differences in pharmacokinetics between different types of glycoprotein IIb/IIIa receptor blockers and a potential rebound prothrombotic effect with the use of these antiplatelet drugs are reviewed.

CARDIAC & CARDIOVASCULAR SYSTEMS