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Li Bassi G, Rigol M, Martí JD, Saucedo L, Ranzani OT, Roca I, Cabanas M, Muñoz L, Giunta V, Luque N, Rinaudo M, Esperatti M, Fernandez-Barat L, Ferrer M, Vila J, Ramírez J, Torres A
A novel porcine model of ventilator-associated pneumonia caused by oropharyngeal challenge with Pseudomonas aeruginosa.
Anesthesiology. 2014 May;120(5):1205-15, PMID: 24618700
Animal models of ventilator-associated pneumonia (VAP) in primates, sheep, and pigs differ in the underlying pulmonary injury, etiology, bacterial inoculation methods, and time to onset. The most common ovine and porcine models do not reproduce the primary pathogenic mechanism of the disease, through the aspiration of oropharyngeal pathogens, or the most prevalent human etiology. Herein the authors characterize a novel porcine model of VAP due to aspiration of oropharyngeal secretions colonized by Pseudomonas aeruginosa.
ANESTHESIOLOGY
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