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Guardiola M, Cofán M, De Castro-Orós I, Cenarro A, Plana N, Talmud PJ, Masana L, Ros E, Civeira F, Ribalta J
APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis.
Atherosclerosis. 2015 May;240(1):98-104, PMID: 25770687
Triglycerides (TG) are the initiators of the metabolic changes leading to the atherogenic dyslipidemia, which is a major inducer of atherosclerosis as a result of quantitative and qualitative changes in lipoprotein subclass distributions. We hypothesized that variation at the of APOA5 gene locus, encoding apoAV, a key regulator of TG levels, significantly affect lipoprotein subclass distributions toward a more atherogenic pattern in both hyperTG patients and dyslipemic patients.
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