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Martin-Rodriguez S, Caballo C, Gutiérrez G, Vera M, Cruzado JM, Cases A, Escolar G, Diaz-Ricart M

TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia.

Eur. J. Clin. Invest.. 2015 Feb;45(2):160-9, PMID: 25496217

The increased cardiovascular risk present in chronic kidney disease (CKD) is related to the development of endothelial dysfunction, whose mechanisms are still unclear. Accumulation of toxins and proinflammatory cytokines may constitute danger-associated molecular patterns (DAMP) to which endothelial cells are continuously exposed. Potential involvement of mechanisms recognizing DAMP, such as TLR and inflammasomes, has been explored.


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