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Araki T, Ikeda N, Dey N, Acharjee S, Molinari F, Saba L, Godia EC, Nicolaides A, Suri JS

Shape-based approach for coronary calcium lesion volume measurement on intravascular ultrasound imaging and its association with carotid intima-media thickness.

J Ultrasound Med. 2015 Mar;34(3):469-82, PMID: 25715368

Coronary calcification plays an important role in diagnostic classification of lesion subsets. According to histopathologic studies, vulnerable atherosclerotic plaque contains calcified deposits, and there can be considerable variation in the extent and degree of calcification. Intravascular ultrasound (IVUS) has demonstrated its role in imaging coronary arteries, thereby displaying calcium lesions. The aim of this work was to develop a fully automated system for detection, area and volume measurement, and characterization of the largest calcium deposits in coronary arteries. Furthermore, we demonstrate the correlation between the coronary calcium IVUS volume and the neurologic risk biomarker B-mode carotid intima-media thickness (IMT).

RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING