Buscador de publicaciones<< Volver
Fernández-Mariño AI, Porras-González C, González-Rodríguez P, Selent J, Pastor M, Ureña J, Castellano A, Valverde MA, Fernández-Fernández JM
Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation.
Cardiovasc. Res.. 2012 Jul;95(1):29-38, PMID: 22473360
Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to evaluate whether BK channel modulation by tungstate can contribute to its antihypertensive effect.
CARDIAC & CARDIOVASCULAR SYSTEMS
Una iniciativa de
