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Galindo P, Rodríguez-Gómez I, González-Manzano S, Dueñas M, Jimenez R, Menendez C, Vargas F, Tamargo J, Santos-Buelga C, Perez-Vizcaino F, Duarte J
Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.
PLoS ONE. 2012;7(3):e32673, PMID: 22427863
Chronic oral quercetin reduces blood pressure and restores endothelial dysfunction in hypertensive animals. However, quercetin (aglycone) is usually not present in plasma, because it is rapidly metabolized into conjugated, mostly inactive, metabolites. The aim of the study is to analyze whether deconjugation of these metabolites is involved in the blood pressure lowering effect of quercetin.
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