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Miguel-Velado E, Pérez-Carretero FD, Colinas O, Cidad P, Heras M, López-López JR, Pérez-García MT
Cell cycle-dependent expression of Kv3.4 channels modulates proliferation of human uterine artery smooth muscle cells.
Cardiovasc. Res.. 2010 Jun;86(3):383-91, PMID: 20093253
Vascular smooth muscle cell (VSMC) proliferation is involved in cardiovascular pathologies associated with unwanted arterial wall remodelling. Coordinated changes in the expression of several K+ channels have been found to be important elements in the phenotypic switch of VSMCs towards proliferation. We have previously demonstrated the association of functional expression of Kv3.4 channels with proliferation of human uterine VSMCs. Here, we sought to gain deeper insight on the relationship between Kv3.4 channels and cell cycle progression in this preparation.
CARDIAC & CARDIOVASCULAR SYSTEMS
Una iniciativa de
