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Cidad P, Moreno-Domínguez A, Roqué M, Novensá L, Barquín L, Heras M, Pérez-García MT, López-López JR

Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells.

Arterioscler. Thromb. Vasc. Biol.. 2010 Jun;30(6):1203-11, PMID: 20299686

Vascular smooth muscle cells (VSMCs) contribute significantly to occlusive vascular diseases by virtue of their ability to switch to a noncontractile, migratory, and proliferating phenotype. Although the participation of ion channels in this phenotypic modulation (PM) has been described previously, changes in their expression are poorly defined because of their large molecular diversity. We obtained a global portrait of ion channel expression in contractile versus proliferating mouse femoral artery VSMCs, and explored the functional contribution to the PM of the most relevant changes that we observed.


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