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Guxens M, Tomás M, Elosua R, Aldasoro E, Segura A, Fiol M, Sala J, Vila J, Fullana M, Sentí M, Vega G, de la Rica M, Marrugat J
[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
Rev Esp Cardiol. 2008 Mar;61(3):269-75, PMID: 18361900
Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk.
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