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Batlle M, Roig E, Pérez-Villa F, Lario S, Cejudo-Martin P, García-Pras E, Ortiz J, Roqué M, Orús J, Rigol M, Heras M, Ramírez J, Jimenez W

Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure.

J. Heart Lung Transplant.. 2006 Sep;25(9):1117-25, PMID: 16962475

The activation of the renin-angiotensin system (RAS) contributes to the progression of left ventricular dysfunction. A novel human homologue of the angiotensin-converting enzyme (ACE), named ACE2, has been described but its role in human heart failure (HF) has not been elucidated. Besides, there is controversy as to whether the major angiotensin II-forming-activity in heart is ACE or chymase released from mast cells. Furthermore, long-term blockade of nitric oxide (NO) synthesis has been shown to increase ACE activity. To assess the locally activated vasoactive mediators that may contribute to the ventricular deterioration process, we sought to simultaneously analyze their expression in failing hearts.

CARDIAC & CARDIOVASCULAR SYSTEMS