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Vázquez E, Valverde MA

A review of TRP channels splicing.

Semin. Cell Dev. Biol.. 2006 Dec;17(6):607-17, PMID: 17174125

Ion channel functional diversity can be achieved at the structural level by means of three main mechanisms: (1) transcriptional regulation and processing of mRNA, (2) heteromerization of different pore-forming channel subunits and (3) incorporation of regulatory subunits to the functional channel complex. In this review article we will focus on one of these mechanisms, alternative pre-mRNA splicing, in the context of the TRP superfamily of cation channels. For this purpose, the basic principles governing pre-mRNA splicing will be introduced and comprehensive tables classifying only published spliced-variants of TRP channels will be presented.


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