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Toral M, Gómez-Guzmán M, Jimenez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo A, Perez-Vizcaino F, Gálvez J, Duarte J

Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.

J. Hypertens.. 2015 Sep;33(9):1831-44, PMID: 26147382

Endothelial dysfunction plays a key role in obesity-induced risk of cardiovascular disease. The aim of the present study was to analyze the effect of chronic peroxisome proliferator-activated receptor (PPAR)β/δ agonist GW0742 treatment on endothelial function in obese mice fed a high-fat diet (HFD).

PERIPHERAL VASCULAR DISEASE