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Martin-Rodriguez S, Reverter JC, Tàssies D, Espinosa G, Heras M, Pino M, Escolar G, Diaz-Ricart M
Reduced ADAMTS13 activity is associated with thrombotic risk in systemic lupus erythematosus.
Lupus. 2015 Oct;24(11):1143-9, PMID: 25824235
Severe deficiency of ADAMTS13 activity leads to von Willebrand factor (VWF) ultralarge multimers with high affinity for platelets, causing thrombotic thrombocytopenic purpura. Other pathological conditions with moderate ADAMTS13 activity exhibit a thrombotic risk. We examined the ADAMTS13 activity in systemic lupus erythematosus (SLE) and its value as a thrombotic biomarker.
RHEUMATOLOGY
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