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Clarimón J, Muñoz FJ, Boada M, Tàrraga L, Sunyer J, Bertranpetit J, Comas D

Possible increased risk for Alzheimer's disease associated with neprilysin gene.

J Neural Transm (Vienna). 2003 Jun;110(6):651-7, PMID: 12768360

Neprilysin has recently been reported to be the major physiological Abeta-degradating enzyme. In this study we describe a new biallelic polymorphism in the 3'UTR of the neprilysin gene in a representative population sample. The (*)159C/C genotype was found to be associated with an increased risk for Alzheimer's disease in an age-dependent manner. Adjusting for sex and APOE status, an odds ratio of 2.74 (p < 0.05) was observed among patients under 75 years old.

CLINICAL NEUROLOGY