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Quintela AM, Jimenez R, Piqueras L, Gómez-Guzmán M, Haro J, Zarzuelo MJ, Cogolludo A, Sanz MJ, Toral M, Romero M, Perez-Vizcaino F, Duarte J
PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.
Br. J. Pharmacol.. 2014 Jun;171(12):3089-102, PMID: 24527778
PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats.
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