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Silvestre-Roig C, Fernández P, Mansego ML, van Tiel CM, Viana R, Viviani Anselmi C, Anselmi CV, Condorelli G, de Winter RJ, Martín-Fuentes P, Solanas-Barca M, Civeira F, Focaccio A, de Vries CJ, Chaves FJ, Andrés V

Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis.

Circ Cardiovasc Genet. 2014 Feb;7(1):59-70, PMID: 24395923

The development of diagnostic tools to assess restenosis risk after stent deployment may enable the intervention to be tailored to the individual patient, for example, by targeting the use of drug-eluting stent to high-risk patients, with the goal of improving safety and reducing costs. The CCNB1 gene (encoding cyclin B1) positively regulates cell proliferation, a key component of in-stent restenosis. Therefore, we hypothesized that single-nucleotide polymorphisms in CCNB1 may serve as useful tools in risk stratification for in-stent restenosis.

CARDIAC & CARDIOVASCULAR SYSTEMS